Association of rs7754840 G/C polymorphisms in CDKAL1 with type 2 diabetes: a meta-analysis of 70141 subjects.

The reported association of the CDKAL1 rs7754840 G/C gene polymorphism with T2DM susceptibility remains controversial. In this study, this association was further investigated using a meta-analysis of 33,149 patients and 36,992 controls from 32 independent studies. The random-effect models were used in order to evaluate the pooled odds ratios (ORs) and their 95% confidence intervals (CIs). A significant relationship between the CDKAL1 rs7754840 G/C gene polymorphism and T2DM was observed under allelic (OR: 1.37, 95% CI: 1.22, 1.55, P < 0.001), recessive (OR: 1.58, 95% CI: 1.20-2.08, P < 0.001), dominant (OR: 1.13, 95% CI: 1.21-1.33, P = 0.01), and homozygous (OR: 1.27, 95% CI: 1.21-1.33, P < 0.001), and heterozygous (OR: 0.83, 95% CI: 0.75-0.93, P < 0.001). Overall, the CDKAL1 rs7754840 G/C gene polymorphism was found to be significantly associated with an increased T2DM risk; the C allele of the CDKAL1 rs7754840 G/C gene polymorphism may confer susceptibility to T2DM.